Soyuz-U | Progress M-12M (44P)

Approximately 325 seconds into flight, a malfunction was detected in the RD-0110 engine powering the Blok I third stage of the Soyuz-U rocket, which caused the onboard computer to terminate the flight through thrust termination. As a result, the vehicle failed to achieve orbit, reentering over the Altai Republic region of Russia. It was the first failure of a Progress spacecraft since launches began in 1978, and the third consecutive orbital launch failure worldwide.